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932 After cerebral I/R injury, Mg 2+ /Mn 2+ dependent 1K (PPM1K) expression in neuronal cells decreases, resulting in increased phosphorylation of BCAAs dehydrogenase E1 subunit (BCKDHA) S293, leading to BCAAs accumulation

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Distribution then occurs rapidly throughout the cortex, hypothalamus, and other brain regions

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