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While in the present study we did not include a group of untreated 5xFAD mice, our previous experience revealed no differences between untreated and IgG-injected mice, neither in the 5xFAD 54 nor DM-hTAU 40 mouse models

Another line of evidence comes from studies on NAD+ and insulin resistance

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(C) schematic, sequences, and helicity characteristics of MAML1-derived SAHM peptides