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References: Science Direct: Nicotine, its metabolism and an overview of its biological effects National Institute of Health (NIH): Nicotine Chemistry, Metabolism, Kinetics and Biomarkers NIH: Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

For tips on how to separate the tobacco from the stem when the leaves are dry, read on

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Integumentary system (skin, hair, and nails) The more obvious signs of smoking involve skin changes

It indicated that the diversity of fungi was superior to bacteria