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The lactate-lactylation axis exerts disease-specific pathogenic roles via distinct core mechanisms: cerebral ischemia features an acute metabolic crisis-driven lactylation of mitochondrial proteins (Zhou et al., 2024)

American Journal of Respiratory Cell and Molecular Biology, 6(2), 235-243

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And FDA regulators agreed, saying later that the substances "present significant safety risks," because most have not been extensively tested in humans

The paper indicates that 7% of children with Down syndrome also have diagnosed or suspected ketotic hypoglycemia