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Combine low intake with impaired absorption, and deficiency becomes highly probable without supplementation

Furthermore, decreased bacterial richness has been linked to high carbohydrate 73 and high-fat/low-protein concentrations 74 , as found in the lean and Western diets, respectively, the latter result only in old-aged rats 74

PMID 16042604

Disclaimer: For research use only

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For comparison, FDA-approved anti-obesity medications like semaglutide 2.4 mg (Wegovy) have cardiovascular outcomes data from the SELECT trial (N=17,604, median follow-up 39.8 months), which demonstrated a 20% reduction in major adverse cardiovascular events [6]