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L.s 2008 study, Neurobiology of nicotine addiction: implications for smoking cessation treatment., Nicotine addiction operates through the alpha4beta2 brain receptor, triggering dopamine release for pleasure and mood effects

Grading of recommendations Recommendations are graded according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system.21 Whether a recommendation is strong or conditional will depend on considerations such as certainty in estimated effects of an intervention, including magnitude, as well as estimates of how patients value and prioritize outcomes, variability of these estimates, and wise use of resources

These effects may include increased inflammation and an imbalance between beneficial and potentially harmful bacterial strains

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Fortunately, quitting smoking leads to a dramatically lower risk of heart disease almost immediately

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