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Interacting NAD(+) and Cell Senescence Pathways Complicate Antiaging Therapies

These changes can culminate in symptoms of fatigue through the action of various cytokines which act on a fatigue nucleus or a collection of neurons dedicated to inhibiting energy-consuming activities that promote focusing on available energy stores for healing (25)

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10.1016/j.tiv.2007.04.004 Toxicol