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112 Upon reaching the liver, bacterial extracellular vesicles function as highly targeted delivery vehicles, independently unloading concentrated packages of virulence factors, microbial small RNAs, and active metabolites directly into hepatic non-parenchymal cells

Matenchuk BA, Mandhane PJ, Kozyrskyj AL

As more ligands are added the electron-electron repulsions keep increasing until the lowering of energy of the ligand electrons in the new bond is insufficient to compensate for the raising of energy of the existing M-L bonding electrons

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Systemic vs