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Allergens or toxins in the urine are thought to cause the bladder walls to become sensitized to increased mast cells.[ref][ref][ref] Vulvodynia and mast cell activation: Vulvodynia is a chronic genital pain condition that includes an increased number of mast cells

Dihexa has gained scientific interest due to its unique biochemical profile and potent binding properties related to cellular mechanisms, synaptic growth, and neuronal differentiation (Wikipedia: Dihexa)

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M.St-GermainC.BlaisE.CrapoJ.et al (2016)