6e) as can be seen from the yellow regions in the overlaid image (Fig
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The reduced thiol group on the cysteine residue directly scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS), becoming oxidized to GSSG in the process
By interfering with this process, FOXO4-DRI frees p53, leading to selective apoptosis of senescent cells without harming healthy ones
and it provides antioxidant protection that reduces oxidative stress-induced hyperpigmentation