B., & Tek, C
This line of research directly informed the development of Dihexa
Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as A 1-42 , -synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide ), but also trigger oxidative stress, damage to the Wnt/-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction
Their clinical appeal lies in their specificitypeptides can mimic naturally occurring signals in the body, producing physiological changes with minimal systemic disruption
Anal Biochem 74:214226 Jaworek J, Leja-Szpak A, Bonior J, Nawrot K, Tomaszewska R, Stachura J, Sendur R, Pawlik W, Brzozowski T, Konturek SJ (2003) Protective effect of melatonin and its precursor L-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion